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Delavirdine delavirdine inhibits the metabolism of indinavir such that coadministration of 400-mg or 600-mg indinavir three times daily with 400-mg delavirdine three times daily alters indinavir auc, c max and c min see table 2 .

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Since indinavir is only a first-generation protease inhibitors, the drug is being increasingly replaced by newer drugs such as lopinavir or atazanavir, which are more convenient to administer and less likely to develop resistance to the virus.

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Genetically determined cyp3a5 expressors had 44 faster indinavir oral clearance versus nonexpressors p 0.

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Medroxyprogesterone major coadministration of medroxyprogesterone, a cyp3a substrate with indinavir, a strong cyp3a inhibitor should be avoided since it is expected to increase concentrations of medroxyprogesterone acetate.

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